Microsatelliteinstability-high

由 C Gutierrez 著作 · 2023 · 被引用 5 次 — MSI-high/MMR deficiency status has emerged as a potent predictive biomarker for response to programmed cell death-1 (PDCD1; ie, PD-1) checkpoint ...

由 R Bonneville 著作 · 2017 · 被引用 1075 次 — Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic microsatellites and is caused by defects in the ...

由 K Li 著作 · 2020 · 被引用 337 次 — The instability of one site is called low microsatellite instability (MSI-L), and the instability of two or more sites is called high ...

Microsatellite instability (MSI) is the condition of genetic hypermutability (predisposition to mutation) that results from impaired DNA mismatch repair ...

2020年10月2日 — Scientists currently define microsatellite instability as an abundance of small DNA changes, like the addition or deletion of one or two DNA ...

由 S Han 著作 · 2022 · 被引用 3 次 — Microsatellite-instability-high (MSI-H) cancers are a unique class of tumors that may arise from somatic inactivating mutations or epigenetic ...

2023年3月6日 — Instability occurs when these genes aren't functioning. As the DNA replicates, errors are introduced and don't get corrected, and as it ...

由 LA Gian 著作 · 2018 · 被引用 174 次 — Samples can be classified into microsatellite instability-high (MSI-H), microsatellite instability-low (MSI-L) or microsatellite stable (MSS) according the ...

Microsatellite instability (MSI) is caused by defects in DNA mismatch repair proteins (MSH2, MLH1, PMS1, PMS2, MSH6, or MSH3). It manifests as an abnormal ( ...